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Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06

Abstract

Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from the fermentation broth of Streptomyces avermitilis HU02-06. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data. Bioassay test showed that these two new tenvermectins exhibited weak nematocidal activity against Bursaphelenchus xylophilus and moderate cytotoxic activity against tumor cell lines HepG2 and HCT116.

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Acknowledgements

This research was financially supported by Zhejiang Provincial Natural Science Foundation of China (Grant No. LGN22B020002), and the Natural Science Foundation of Huzhou City (Grant no. 2022YZ08).

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Correspondence to Ji-dong Wang or Wen-sheng Xiang.

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Zhang, H., Wang, Zy., Qi, H. et al. Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06. J Antibiot (2024). https://doi.org/10.1038/s41429-024-00754-y

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  • DOI: https://doi.org/10.1038/s41429-024-00754-y

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