Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06


Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 (1) and aromatic TVM B (2), were isolated from the fermentation broth of Streptomyces avermitilis HU02-06. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR and HRESIMS data. Bioassay test showed that these two new tenvermectins exhibited weak nematocidal activity against Bursaphelenchus xylophilus and moderate cytotoxic activity against tumor cell lines HepG2 and HCT116.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

Similar content being viewed by others


  1. Zhang J, et al. Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. Microb Cell Fact. 2015;14:152–63.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Huang J, et al. Gene replacement for the generation of designed novel avermectin derivatives with enhanced acaricidal and nematicidal activities. Appl Environ Microbiol. 2015;81:5326–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Wan X, et al. New tenvermectin analogs obtained by microbial conversion with Saccharopolyspora erythraea. J Antibiot. 2017;70:190–2.

    Article  CAS  Google Scholar 

  4. Zhang H, et al. Acyltransferase domain swapping for the production of tenvermectin B metabolites in genetically engineered strain Streptomyces avermitilis HU02. J Agric Food Chem. 2022;70:11994–2003.

    Article  CAS  PubMed  Google Scholar 

  5. Wang JD, et al. HS071, a new furan-type cytotoxic metabolite from Streptomyces sp. HS-HY-071. J Antibiot. 2008;61:623–26.

    Article  CAS  Google Scholar 

  6. Xiang WS, Wang JD, Wang XJ, Zhang J. A novel macrolide compound from Streptomyces bingchenggensis: fermentation, isolation, structure elucidation and biological properties. J Antibiot. 2009;62:229–31.

    Article  CAS  Google Scholar 

  7. Sklavounos C, Demers N, Lukaszewicz J, Nowakowski M. Photoisomerization of aromatic doramectin derivatives. J Agric Food Chem. 1994;42:1228–31.

    Article  CAS  Google Scholar 

  8. Tway TC, Wood JS Jr, Downing GV. Determination of ivermectin in cattle and sheep tissues using high-performance liquid chromatography with fluorescence detection. J Agric Food Chem. 1981;29:1059–63.

    Article  CAS  PubMed  Google Scholar 

  9. Stong JD. Determination of ivermectin by fluorescence derivatization. Anal Chem. 1987;59:266–70.

    Article  CAS  PubMed  Google Scholar 

  10. Hoti Q, Rustem DG, Dalmizrak O. Avermectin B1a shows potential anti-proliferative and anticancer effects in HCT-116 cells via enhancing the stability of microtubules. Curr Issues Mol Biol. 2023;45:6272–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references


This research was financially supported by Zhejiang Provincial Natural Science Foundation of China (Grant No. LGN22B020002), and the Natural Science Foundation of Huzhou City (Grant no. 2022YZ08).

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Ji-dong Wang or Wen-sheng Xiang.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, H., Wang, Zy., Qi, H. et al. Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06. J Antibiot (2024).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI:


Quick links