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Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima


Investigation of cultures of the basidiomycete Favolaschia minutissima TBRC-BCC 19434 led to the isolation of two undescribed β-methoxyacrylate metabolites, 9-methoxystrobilurins R (1) and S (2), and a degraded aldehyde derivative, favodehyde E (3). 9-Methoxystrobilurin derivatives 1 and 2 exhibited significant antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC50 values of 0.12 and 0.21 μM, respectively.

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Financial supports from National Research Council of Thailand (NRCT) (Grant No. N42A660851) is gratefully acknowledged.

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Correspondence to Masahiko Isaka.

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Palasarn, S., Srichomthong, K., Thummarukcharoen, T. et al. Antimalarial 9-methoxystrobilurin derivatives from cultures of the basidiomycete Favolaschia minutissima. J Antibiot 77, 422–427 (2024).

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