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Okichromanone, a new antiviral chromanone from a marine-derived Microbispora


Okichromanone (1), a new chromanone, was isolated from the culture extract of a sponge-derived actinomycete Microbispora, along with known 1-hydroxyphenazine (2). Compound 1 was elucidated to exist as a mixture of two isomeric structures (1a and 1b) at a ratio of nearly 3:2. Compounds 1 and 2 showed anti HSV-I activity with IC50 values 40 and 86 μM, respectively, and anti HSV-II activity with IC50 values 59 and 123 μM, respectively.

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Correspondence to Marwa Elsbaey.

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Elsbaey, M., Jomori, T., Tanaka, J. et al. Okichromanone, a new antiviral chromanone from a marine-derived Microbispora. J Antibiot 77, 389–392 (2024).

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