The filamentous fungus Synnemellisia sp. strain FKR-0921 was obtained from soil collected on Kume Island, Okinawa. The MeOH extract of FKR-0921 cultured on a solid rice medium yielded a new aromatic compound, synnemellisitriol A (1). The structure, including the absolute configuration, was elucidated by spectroscopic analysis (FT-IR, NMR, and HR-ESI-MS), and the absolute configuration at C-9 of 1 was determined using the modified Mosher’s method. Additionally, 1 was evaluated for its biological activities, including metallo-β-lactamase inhibitory activity, type III secretion system inhibitory activity, antimicrobial activity, antimalarial activity, and cytotoxicity.
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We are grateful to Mr. Shinichi Gima (Center for Research Advancement and Collaboration, University of the Ryukyus) for the HR-ESI-MS measurements. We are grateful to the distinguished Emeritus Professor Satoshi Ōmura (Kitasato University) for his helpful support, valuable guidance, and insightful suggestions. Furthermore, we acknowledge the English language editing provided by Editage (www.editage.com). This study was supported by the Okinawan Create Leading Projects in Growing Fields 2017–2019, Okinawan Create Leading Projects in Growing Fields 2020–2021, and OKINAWA Prefectural Government. This research was partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) from AMED under Grant Numbers JP21am0101096 (Phase I) and JP22ama121035 (Phase II).
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Tahara, A., Tani, K., Wakatsuki, M. et al. A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921. J Antibiot 76, 706–710 (2023). https://doi.org/10.1038/s41429-023-00657-4