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Amamine, an isoquinoline alkaloid from the Kitasatospora sp. HGTA304

The Journal of Antibiotics volume 76, pages 623–625 (2023)Cite this article

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Abstract

Amamine (1), a new isoquinoline alkaloid, was isolated from the culture extract of an actinomycete Kitasatospora sp. HGTA304. The structure of 1 was determined by NMR and MS analyses in combination with UV data. Compound 1 displayed α-glucosidase inhibitory potential (IC50 value of 56 μM) compared with acarbose (IC50 value of 549 μM) as standard.

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Fig. 1

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Acknowledgements

This work was supported by JSPS KAKENHI Grant Number JP19K07135 (T.K.) and Useful and Unique Natural Products for Drug Discovery and Development (UpRod), Program for Building Regional Innovation Ecosystems at Kumamoto University, Japan.

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  1. Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan

    Teppei Kawahara, Marin Ueda, Naoki Kishimoto, Tae Yasutake, Shogo Misumi, Hari Prasad Devkota & Mikiyo Wada

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  1. Teppei Kawahara
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  2. Marin Ueda
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Correspondence to Teppei Kawahara.

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Kawahara, T., Ueda, M., Kishimoto, N. et al. Amamine, an isoquinoline alkaloid from the Kitasatospora sp. HGTA304. J Antibiot 76, 623–625 (2023). https://doi.org/10.1038/s41429-023-00641-y

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  • DOI: https://doi.org/10.1038/s41429-023-00641-y

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