Amamine (1), a new isoquinoline alkaloid, was isolated from the culture extract of an actinomycete Kitasatospora sp. HGTA304. The structure of 1 was determined by NMR and MS analyses in combination with UV data. Compound 1 displayed α-glucosidase inhibitory potential (IC50 value of 56 μM) compared with acarbose (IC50 value of 549 μM) as standard.
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This work was supported by JSPS KAKENHI Grant Number JP19K07135 (T.K.) and Useful and Unique Natural Products for Drug Discovery and Development (UpRod), Program for Building Regional Innovation Ecosystems at Kumamoto University, Japan.
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Kawahara, T., Ueda, M., Kishimoto, N. et al. Amamine, an isoquinoline alkaloid from the Kitasatospora sp. HGTA304. J Antibiot 76, 623–625 (2023). https://doi.org/10.1038/s41429-023-00641-y