There are six new phthalide derivatives Verbalide A ~ F (1–6) together with another known derivative (7) isolated from the endophytic fungus Preussia sp. CPCC 400972. Their structures were established by comprehensive spectroscopic analyses, including NMR and HRESIMS. In addition, compounds 1–7 exhibited excellent inhibitory effect against influenza A virus.
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This work was financially supported by the National Natural Science Foundation of China (No. 81973220), CAMS Innovation Fund for Medical Sciences (No. 2021-I2M-1-055), the National Microbial Resource Center (No. NMRC-2022-3).
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Zhang, R., Wang, Y., Cai, G. et al. Verbalide A~F: new phthalide derivatives from the endophytic fungus Preussia sp. CPCC 400972. J Antibiot 76, 613–617 (2023). https://doi.org/10.1038/s41429-023-00640-z