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New meroterpenoids from a soil-derived fungus Penicillium sp. SSW03M2 GY and their anti-virulence activity

The Journal of Antibiotics volume 76, pages 57–64 (2023)Cite this article

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Abstract

Two new berkeley meroterpenoids (1 and 2), along with seven known compounds (3‒9) were isolated from a fungus, Penicillium sp. SSW03M2 GY derived from a sediment at Seosan bay, South Korea. Chemical structures of the isolated compounds were elucidated on the basis of 1D, 2D NMR, HRESIMS, and optical rotation. All the isolated compounds, 1 showed anti-virulence activity by significantly inhibiting α-toxin (Hla) secreted by methicillin-resistant Staphylococcus aureus without its growth inhibition.

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Acknowledgements

This work was supported by the National Research Foundation (NRF) of Korea (NRF-2021R1A2C1004958 and NRF-2022R1A4A3022401).

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Authors and Affiliations

  1. Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea

    Hyeri Ku, Seungjin Lee & Sang Hee Shim

  2. College of Science and Technology, Duksung Women’s University, Seoul, Republic of Korea

    Yeonhee Lee & Hwang-soo Joo

  3. College of Pharmacy, Duksung Women’s University, Seoul, Republic of Korea

    Jin Woo Lee

  4. Department of Biomedical Science and Engineering, Konkuk University, Seoul, Republic of Korea

    Hahk-Soo Kang

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  1. Hyeri Ku
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Correspondence to Sang Hee Shim.

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Ku, H., Lee, Y., Lee, S. et al. New meroterpenoids from a soil-derived fungus Penicillium sp. SSW03M2 GY and their anti-virulence activity. J Antibiot 76, 57–64 (2023). https://doi.org/10.1038/s41429-022-00587-7

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