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A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410


A novel 3,4-dihydroisocoumarin glycoside (1) was obtained from the culture of endophytic fungal Xylaria CGMCC No.5410 from the leaves of Selaginella moellendorffii Hieron, together with five known compounds (2–6). Their structures elucidations were conducted by HRESIMS, NMR and IR spectroscopic analysis. All the isolated compounds were evaluated for their antimicrobial, anti-tumor, and anti-HIV-1 activities. Compound 1 only displayed weak antimicrobial activity against micrococcus luteus. The other known compounds showed different antimicrobial, anti-tumor, or anti-HIV-1 activities.

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The work was supported in part by grants from the Shanghai Natural Science Foundation (20ZR1424600).

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ZJY performed the experiments, with the assistance of KW, WLJ and XJW. YY offered the fungal source. LS, MG and YXY designed the research. ZJY, MG and YXX wrote the paper.

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Correspondence to Mei Ge or Yixin Xu.

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The authors declare no competing interests.

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Yang, Z., Wu, K., Ji, W. et al. A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410. J Antibiot 76, 239–243 (2023).

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