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A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410

The Journal of Antibiotics volume 76, pages 239–243 (2023)Cite this article

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Abstract

A novel 3,4-dihydroisocoumarin glycoside (1) was obtained from the culture of endophytic fungal Xylaria CGMCC No.5410 from the leaves of Selaginella moellendorffii Hieron, together with five known compounds (2–6). Their structures elucidations were conducted by HRESIMS, NMR and IR spectroscopic analysis. All the isolated compounds were evaluated for their antimicrobial, anti-tumor, and anti-HIV-1 activities. Compound 1 only displayed weak antimicrobial activity against micrococcus luteus. The other known compounds showed different antimicrobial, anti-tumor, or anti-HIV-1 activities.

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Fig. 1
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Acknowledgements

The work was supported in part by grants from the Shanghai Natural Science Foundation (20ZR1424600).

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Authors and Affiliations

  1. School of Pharmacy, Shanghai University of Medine&Health Sciences, Shanghai, China

    Zhijun Yang, Kai Wu, Wangli Ji & Yixin Xu

  2. Microbial Pharmacology Laboratory, Shanghai University of Medine & Health Sciences, Shanghai, China

    Zhijun Yang, Kai Wu, Xiaojing Wang & Lei Shao

  3. Shanghai Laiyi Center for Biopharmaceutical R&D, Shanghai, China

    Yu Yin & Mei Ge

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  1. Zhijun Yang
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  2. Kai Wu
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  3. Wangli Ji
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  4. Yu Yin
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  7. Mei Ge
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  8. Yixin Xu
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Contributions

ZJY performed the experiments, with the assistance of KW, WLJ and XJW. YY offered the fungal source. LS, MG and YXY designed the research. ZJY, MG and YXX wrote the paper.

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Correspondence to Mei Ge or Yixin Xu.

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Yang, Z., Wu, K., Ji, W. et al. A novel biologically active xylaphenoside from the endophytic fungus Xylaria CGMCC No.5410. J Antibiot 76, 239–243 (2023). https://doi.org/10.1038/s41429-022-00586-8

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  • DOI: https://doi.org/10.1038/s41429-022-00586-8

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