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p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea

The Journal of Antibiotics volume 76, pages 52–55 (2023)Cite this article

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Abstract

A new p-terphenyl derivative, hydroxystrepantibin D (1), was isolated along with two known p-terphenyls (2 and 3) from the culture broth of Phlebiopsis castanea. These compounds were isolated using silica gel column chromatography, reversed-phase medium-pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined based on spectroscopic methods. These compounds exhibited free radical scavenging activities with IC50 values in the range from 22.2 to 158.4 μM against 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical and in the range from 161.1 to 356.1 μM against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.

The members of p-terphenyls are characterized by a central benzene ring substituted with two phenyl groups on para-position. This class of compounds consists of naturally occurring terphenyls that are more common than ortho- and meta-terphenyls. More than 230 natural p-terphenyls have been isolated from microorganisms, such as basidiomycetes, ascomycetes, and streptomycetes [1,2,3]. These compounds have exhibited cytotoxic activity against HL60, HCC1954, HeLa, and HCT116 cancer cell lines [1, 4], neuroprotective activity [5], antioxidant activity [6, 7], antimicrobial activity [8, 9], antiplatelet activity in rat platelet [10], and α-glucosidase inhibitory activity [11].

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Acknowledgements

The authors thank Ms. Ji-Young Oh, Center for University-wide Research Facilities (CURF) at Jeonbuk National University for performing NMR measurements.

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  1. Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, Korea

    Dae-Cheol Choi, Dae-Won Ki, In-Kyoung Lee & Bong-Sik Yun

  2. Department of Genetic Resources Research, National Marine Biodiversity Institute of Korea, Seocheon, Korea

    Ji-Yul Kim

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  1. Dae-Cheol Choi
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Correspondence to Bong-Sik Yun.

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Choi, DC., Ki, DW., Kim, JY. et al. p-Terphenyl glucosides from the culture broth of Phlebiopsis castanea. J Antibiot 76, 52–55 (2023). https://doi.org/10.1038/s41429-022-00579-7

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  • DOI: https://doi.org/10.1038/s41429-022-00579-7

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