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Plant growth-promoting and antimicrobial chloropyrroles from a rare actinomycete of the genus Catellatospora

Abstract

Two new chloropyrroles, designated catellatopyrroles A (1) and B (2), along with 2-(2′-hydroxybenzoyl)pyrrole (3), were isolated from a culture extract of an actinomycete of the genus Catellatospora. The structures of 13 were elucidated through interpretation of NMR and MS data. Compounds 1 and 2 are the first chloropyrroles substituted by an aliphatic acyl group at the 5-position. Compounds 13 promoted root elongation of germinated lettuce seeds at 1–10 μM. While all compounds inhibited the growth of Gram-positive bacteria, activity against Gram-negative bacterium Rhizobium radiobacter and yeasts Candida albicans and Saccharomyces cerevisiae was varied. Compounds 1 and 2 were moderately cytotoxic against P388 cells.

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Acknowledgements

We thank Mr. Masaru Watanabe at Yamanashi University for SEM sample preparation. P388 cells were obtained from JCRB Cell Bank under an accession code JCRB0017 (Lot. 06252002). This work was supported by JSPS KAKENHI Grant Number 19K05848 to YI.

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Correspondence to Yasuhiro Igarashi.

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Liu, C., Yamamura, H., Hayakawa, M. et al. Plant growth-promoting and antimicrobial chloropyrroles from a rare actinomycete of the genus Catellatospora. J Antibiot 75, 655–661 (2022). https://doi.org/10.1038/s41429-022-00567-x

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