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Plant growth-promoting and antimicrobial chloropyrroles from a rare actinomycete of the genus Catellatospora

The Journal of Antibiotics volume 75, pages 655–661 (2022)Cite this article

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Abstract

Two new chloropyrroles, designated catellatopyrroles A (1) and B (2), along with 2-(2′-hydroxybenzoyl)pyrrole (3), were isolated from a culture extract of an actinomycete of the genus Catellatospora. The structures of 1–3 were elucidated through interpretation of NMR and MS data. Compounds 1 and 2 are the first chloropyrroles substituted by an aliphatic acyl group at the 5-position. Compounds 1–3 promoted root elongation of germinated lettuce seeds at 1–10 μM. While all compounds inhibited the growth of Gram-positive bacteria, activity against Gram-negative bacterium Rhizobium radiobacter and yeasts Candida albicans and Saccharomyces cerevisiae was varied. Compounds 1 and 2 were moderately cytotoxic against P388 cells.

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Acknowledgements

We thank Mr. Masaru Watanabe at Yamanashi University for SEM sample preparation. P388 cells were obtained from JCRB Cell Bank under an accession code JCRB0017 (Lot. 06252002). This work was supported by JSPS KAKENHI Grant Number 19K05848 to YI.

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Author notes

  1. Masayuki Hayakawa

    Present address: Yamanashi Prefectural University, Iida 5-11-1, Kofu, Yamanashi, 400-0035, Japan

Authors and Affiliations

  1. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama, 939-0398, Japan

    Chang Liu, Zhiwei Zhang, Naoya Oku & Yasuhiro Igarashi

  2. Department of Biotechnology, Faculty of Life and Environmental Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, 400-8510, Yamanashi, Japan

    Hideki Yamamura & Masayuki Hayakawa

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  1. Chang Liu
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Correspondence to Yasuhiro Igarashi.

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Liu, C., Yamamura, H., Hayakawa, M. et al. Plant growth-promoting and antimicrobial chloropyrroles from a rare actinomycete of the genus Catellatospora. J Antibiot 75, 655–661 (2022). https://doi.org/10.1038/s41429-022-00567-x

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