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A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain


A novel vicinal diepoxide of alloaureothin was isolated from Streptomyces sp. NIIST-D31 strain along with three carboxamides, p-aminobenzoic acid and 1,6-dimethoxyphenazine. Exhaustive 2D NMR analysis and analysis of experimental, theoretical CD spectra aided in establishing the structure of compound 1. Compound 1 inhibits adipogenesis and accumulation of lipid droplets during the differentiation of 3T3-L1 cells.

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Financial support from DST, Science, and Engineering Research Board, India (Grant number: CRG/2020/004993) is gratefully acknowledged. TD, DKI, MSP, and ARSJ are grateful to UGC and CSIR for senior research fellowship.

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Correspondence to Ravi S. Lankalapalli.

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Drissya, T., Induja, D.K., Poornima, M.S. et al. A novel aureothin diepoxide derivative from Streptomyces sp. NIIST-D31 strain. J Antibiot 75, 491–497 (2022).

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