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1,4,6-trihydroxy-8-alkylated-9,10-anthraquinones with antibacterial activities from soil-derived Streptomyces sp. WS-13394

The Journal of Antibiotics volume 75, pages 375–379 (2022)Cite this article

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Abstract

Two new 1,4,6-trihydroxy-8-alkylated-9,10-anthraquinones (1–2) were isolated from the culture broth of the soil actinomycete Streptomyces sp. WS-13394. Their structures were elucidated on the basis of extensive spectroscopic analysis, including mass spectrometry (MS), nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD). Compounds 1 and 2, together with eight analogs (3–10), were evaluated for their antibacterial activities against five pathogens. The tested derivatives of alkylated anthraquinone exhibited selective activities to Gram-positive bacteria, while compounds 1 and 5 showed obvious activities against two zoonotic pathogens, Erysipelothrix rhusiopathiae and Streptococcus suis, with MIC values ranging from 3.13 to 12.5 µg ml−1.

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Acknowledgements

This research was financially supported by Natural Science Foundation of Hubei Province, China (2021CFB070) and Hubei Agricultural Science and Technology Innovation Center (2019-620-000-001-027).

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  1. These authors contributed equally: Zhaoyuan Wu, Manli Liu

Authors and Affiliations

  1. Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, No. 8, Nanhu Ave., Hongshan District, Wuhan, 430064, China

    Zhaoyuan Wu, Manli Liu, Kui Li, Fang Liu, Fei Zhang, Yani Zhang, Kaimei Wang & Wei Fang

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  1. Zhaoyuan Wu
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Correspondence to Wei Fang.

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Wu, Z., Liu, M., Li, K. et al. 1,4,6-trihydroxy-8-alkylated-9,10-anthraquinones with antibacterial activities from soil-derived Streptomyces sp. WS-13394. J Antibiot 75, 375–379 (2022). https://doi.org/10.1038/s41429-022-00533-7

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  • DOI: https://doi.org/10.1038/s41429-022-00533-7

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