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Citrinadin C, a new cytotoxic pentacyclic alkaloid from marine-derived fungus Penicillium citrinum

The Journal of Antibiotics volume 75, pages 301–303 (2022)Cite this article

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Abstract

A new cytotoxic pentacyclic alkaloid, citrinadin C (1), together with four known compounds (2–5), were isolated from deep-sea-derived fungus Penicillium citrinum. The structure of new compound 1 was elucidated by extensive 1D and 2D NMR and Mass spectroscopic data, and its absolute configuration was determined by CD spectrum. All the compounds were evaluated for their cytotoxic and antibacterial activities. Compound 1 showed cytotoxic activities against human liver cancer cell line MHCC97H, with IC50 value of 16.7 μM. Compound 4 displayed significant antibacterial activity against phytopathogen Xanthomonas campestris, with MIC value of 25 μM.

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Acknowledgements

The authors are grateful to the National Natural Science Foundation of China (41206130) for financial support.

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Authors and Affiliations

  1. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, PR China

    Jinyan Jiang, Haimei Jiang, Danni Shen, Yuchi Chen, Huajun Shi & Fei He

  2. Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, PR China

    Fei He

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Correspondence to Fei He.

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Jiang, J., Jiang, H., Shen, D. et al. Citrinadin C, a new cytotoxic pentacyclic alkaloid from marine-derived fungus Penicillium citrinum. J Antibiot 75, 301–303 (2022). https://doi.org/10.1038/s41429-022-00516-8

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