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Nigirpexin E, a new azaphilone derivative with anti-tobacco mosaic virus activity from soil-derived fungus Trichoderma afroharzianum LTR-2

The Journal of Antibiotics volume 75, pages 117–121 (2022)Cite this article

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Abstract

A new compound classified as one new azaphilone derivative, nigirpexin E (1), was obtained from the soil-derived fungus Trichoderma afroharzianum LTR-2, together with seven known compounds (2–8). The structures of 1–8 were determined by their HRESIMS, optical rotation, and NMR spectroscopic data. The absolute configuration of nigirpexin E (1) was determined on the basis of comparisons of experimental and theoretically calculated ECD spectra. Compound 3 was firstly isolated from Trichoderma. Bioactivities of the isolated compounds were assayed their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 1 exhibited significant inactivation effect against TMV with an inhibition rate of 67.25% (0.5 mg ml−1), which was higher than that of positive control ribavirin (56.74%). This is the first report of the anti-TMV activity of azaphilone derivatives.

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Acknowledgements

Young Scientists Partner Project between Shenyang Branch of Chinese Academy of Sciences and Shandong Academy of Sciences (5th) and the National Natural Science Foundation of China (41776178).

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Authors and Affiliations

  1. Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 110016, PR China

    Xueying Xie, Zexi Zhao, Huaqi Pan, Jiangchun Hu & Yan Bai

  2. Shandong Key Laboratory of Applied Microbiology, Ecology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, PR China

    Xueying Xie & Hetong Yang

  3. National Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian, 270108, PR China

    Changxiang Zhu

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  1. Xueying Xie
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Correspondence to Jiangchun Hu or Yan Bai.

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41429_2021_485_MOESM1_ESM.docx

Nigirpexin E, a new azaphilone derivative with anti-tobacco mosaic virus activity from soil-derived fungus Trichoderma afroharzianum LTR-2

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Xie, X., Zhao, Z., Yang, H. et al. Nigirpexin E, a new azaphilone derivative with anti-tobacco mosaic virus activity from soil-derived fungus Trichoderma afroharzianum LTR-2. J Antibiot 75, 117–121 (2022). https://doi.org/10.1038/s41429-021-00485-4

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