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Alternariasin A, new pentacyclic cytochalasin from the fungus Alternaria alternate

The Journal of Antibiotics volume 74, pages 596–600 (2021)Cite this article

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Abstract

Alternariasin A (1), one new cytochalasin possessing the benzo[4,5]indeno[2,1-d]isoindole-1,3,13(2H,3aH)-trione skeleton, and five known compounds 2−6 were isolated from the solid cultures of the Midui Glacier-derived fungus Alternaria alternata. Their structures were elucidated by NMR and MS spectroscopic analyses and by a comparison with data from the literature. The absolute configuration of 1 was assigned by combination of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 displayed antibacterial activity against the S. aureus, B. subtilis and E. coli with MIC values of 16.7, 16.7 and 33.3 μΜ, respectively. While compound 3 showed potent cytotoxicity against a small panel of human tumour cell lines.

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Fig. 1
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Scheme 1

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (32022002, 21772228 and 21977113).

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Authors and Affiliations

  1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    Zhe Guo, Ruiyun Huo, Xingzhong Liu & Ling Liu

  2. University of Chinese Academy of Sciences, Beijing, China

    Zhe Guo, Ruiyun Huo & Ling Liu

  3. School of Biological Medicine, Beijing City University, Beijing, China

    Shubin Niu

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  1. Zhe Guo
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Correspondence to Ling Liu.

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Guo, Z., Huo, R., Niu, S. et al. Alternariasin A, new pentacyclic cytochalasin from the fungus Alternaria alternate. J Antibiot 74, 596–600 (2021). https://doi.org/10.1038/s41429-021-00443-0

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