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6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone


A novel angucyclinone, 6,9-dihydroxytetrangulol, was isolated from Streptomyces lividans TK23 transformed with a kinanthraquinone biosynthetic gene cluster in which the kiqO gene was disrupted. The chemical structure was elucidated by spectroscopic analyses. It showed significant antibacterial activities with an IC50 value of 1.9 μM against Staphylococcus aureus and moderate anticancer activities against HL-60 cells.

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We thank Prof. Haruo Ikeda and Prof. Hiroyasu Onaka for providing the pKU592 and pTYM19 vectors, respectively. This work was supported by JSPS KAKENHI Grant Number 20H00416 to (ST).

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Correspondence to Shunji Takahashi.

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Sakai, K., Takao, R., Koshino, H. et al. 6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone. J Antibiot 74, 593–595 (2021).

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