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Saccharobipyrimicin, a new antibiotic from the leaf-litter actinomycete Saccharothrix sp. MM696L-181F4

The Journal of Antibiotics volume 74, pages 470–473 (2021)Cite this article

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Abstract

In the course of screening for new antimicrobial compounds, a new antibiotic substance named saccharobipyrimicin was isolated from the leaf-litter actinomycete Saccharothrix sp. MM696L-181F4. The structure of saccharobipyrimicin was elucidated by various spectral methods, mainly single-crystal X-ray analysis and chemical degradation. It revealed that saccharobipyrimicin contained a 2,2′-bipyridine skeletal structure. Saccharobipyrimicin showed moderate and broad-spectrum antimicrobial activity. Two chemical derivatives of saccharobipyrimicin showed weaker antimicrobial activities than that of saccharobipyrimicin against most test microorganisms except two tolC mutants of Escherichia coli and Neisseria gonorrhoeae.

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Acknowledgements

We thank Y. Kubota, Y. Takahashi, and Y. Shibuya for providing technical assistance. We thank the National Bioresource Project: E. coli, and the National Institute of Genetics, Japan, for providing the E. coli tolC (efflux-deficient) strain CAG12184. We thank Dr. Ohnishi for providing the N. gonorrhoeae mtrR promoter mutated (drug-resistant) strain FC428. We thank Renee Mosi, Ph.D., from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this paper.

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  1. Institute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan

    Yasuhiro Takehana, Hideyuki Muramatsu, Maya Umekita, Chigusa Hayashi, Tomoyuki Kimura, Ryuichi Sawa & Masayuki Igarashi

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  1. Yasuhiro Takehana
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  2. Hideyuki Muramatsu
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Correspondence to Yasuhiro Takehana or Masayuki Igarashi.

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Takehana, Y., Muramatsu, H., Umekita, M. et al. Saccharobipyrimicin, a new antibiotic from the leaf-litter actinomycete Saccharothrix sp. MM696L-181F4. J Antibiot 74, 470–473 (2021). https://doi.org/10.1038/s41429-021-00418-1

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