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Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389

Abstract

A new member of the dunaimycin family, dunaimycin C3 (2), was isolated from a fermented broth of Streptomyces sp. RAN389. The molecular formula of 2 was established as C42H70O10 by high-resolution FAB-MS, and the structure was elucidated by NMR spectroscopic analyses. Dunaimycin C3 inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC50 of 8.4 nM.

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Acknowledgements

We are grateful to Ms. F. Hasegawa for assistance with mass spectrometry.

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Correspondence to Yoichi Hayakawa.

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Hayakawa, Y., Yoshida, T., Kimata, S. et al. Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389. J Antibiot 74, 76–79 (2021). https://doi.org/10.1038/s41429-020-0356-8

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  • DOI: https://doi.org/10.1038/s41429-020-0356-8

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