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Highly oxygenated angucycline from Streptomyces sp. KCB15JA014

The Journal of Antibiotics volume 73, pages 859–862 (2020)Cite this article

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Abstract

LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (1), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular dichroism calculation. Compound 1 showed weak inhibitory activity against indoleamine 2,3-dioxygenase.

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Acknowledgements

This work was supported by a National Research Council of Science & Technology (NST) grant (ASIA-16-001 and CAP-16-03-KRIBB) and the KRIBB Research Initiative Program funded by the Ministry of Science ICT (MSIT) of the Republic of Korea. We thank the Korea Basic Science Institute, Ochang, Korea, for providing the NMR (700 and 900 MHz), HRESIMS, and CD data.

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Authors and Affiliations

  1. Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Korea

    Gil Soo Kim, Byeongsan Lee, Tae Hoon Oh, Mincheol Kwon, Jun-Pil Jang, Young-Soo Hong & Jong Seog Ahn

  2. Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology, Daejeon, 34113, Korea

    Gil Soo Kim, Mincheol Kwon, Young-Soo Hong, Jae-Hyuk Jang & Jong Seog Ahn

  3. College of Pharmacy, Yeungnam University, Gyeongsan, 38541, Korea

    Geum Jin Kim & Hyukjae Choi

  4. College of Pharmacy, Chungbuk National University, Cheongju, 28160, Korea

    Byeongsan Lee & Tae Hoon Oh

  5. Korean Collection for Type Cultures, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, 56212, Korea

    Jung-Sook Lee

  6. Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Korea

    Sung-Kyun Ko & Jae-Hyuk Jang

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  1. Gil Soo Kim
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Correspondence to Jae-Hyuk Jang or Jong Seog Ahn.

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Kim, G.S., Kim, G.J., Lee, B. et al. Highly oxygenated angucycline from Streptomyces sp. KCB15JA014. J Antibiot 73, 859–862 (2020). https://doi.org/10.1038/s41429-020-0348-8

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