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Bitter compounds in two Tricholoma species, T. aestuans and T. virgatum

The Journal of Antibiotics volume 73, pages 697–701 (2020)Cite this article

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Abstract

Lascivol was identified as the bitter compound in two Tricholoma species, T. aestuans and T. virgatum, and was previously isolated from the European mushroom T. lascivum. The structure of lascivol was previously solved by X-ray crystallographical analysis but its stereochemistry at C3 remained ambiguous. We thus re-examined the absolute configuration of C3 bearing a hydroxy group using the modified Mosher’s method.

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Acknowledgements

The authors thank to Mr. Makoto Hashiya, Dr. Katsuhiro Konno, Mr. Shigeo Morimoto, Mr. Yasukazu Ohkubo, Mr. Shigekazu Habu, Mr. Juichi Ooyama for their help in collecting the mushroom samples and identification of the species. This work was partly supported by KAKENHI (Grants-in-Aid for Challenging Exploratory Research; Grant Number JP25560409) from Japan Society for the Promotion of Science (JSPS) to KH and a Grant-in Aid for Scientific Research on Innovative Areas ‘.Frontier Research on Chemical Communications’ (No 117H06402) to HK.

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Authors and Affiliations

  1. Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan

    Yumiko Oba & Hirokazu Kawagishi

  2. Department of Chemistry for Life Sciences and Agriculture, Faculty of Life Sciences, Tokyo University of Agriculture, Tokyo, Japan

    Makoto Urai, Motohiro Tomizawa & Kimiko Hashimoto

  3. Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan

    Jing Wu & Hirokazu Kawagishi

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  1. Yumiko Oba
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  2. Makoto Urai
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  4. Motohiro Tomizawa
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Correspondence to Kimiko Hashimoto.

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Oba, Y., Urai, M., Wu, J. et al. Bitter compounds in two Tricholoma species, T. aestuans and T. virgatum. J Antibiot 73, 697–701 (2020). https://doi.org/10.1038/s41429-020-0338-x

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  • DOI: https://doi.org/10.1038/s41429-020-0338-x

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