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Two novel milbemycin derivatives from the genetically engineered strain Streptomyces avermitilis AVE-H39

The Journal of Antibiotics volume 73, pages 642–645 (2020)Cite this article

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Abstract

Two novel milbemycin derivatives, 5,27-epoxy-13α-hydroxy milbemycin β11 (1) and 5,27-epoxy-13α-hydroxy-25-ethyl milbemycin β11 (2), were isolated from the genetically engineered strain Streptomyces avermitilis AVE-H39. Their structures were elucidated through the interpretation of HR-ESIMS and extensive NMR spectroscopic data. Compounds 1 and 2 exhibited moderate acaricidal and nematicidal activities.

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Acknowledgements

This research was financially supported by the Key Research and Development Programs of Zhejiang Province (Grant Nos. 2020C02028, 2019C02030, 2019C02024) and the Zhejiang Provincial Natural Science Foundation of China (HX2019069, HX2019078).

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Authors and Affiliations

  1. Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou, China

    Huan Qi, Shao-Yong Zhang, Li-Qin Zhang & Ji-Dong Wang

  2. Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin, China

    Ji Zhang & Wen-Sheng Xiang

  3. Institute of Applied Biotechnology, School of Medicine and Pharmaceutical Engineering, Taizhou Vocational and Technical College, Taizhou, China

    Zhi-Kui Hao & Jian-Song Li

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  1. Huan Qi
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Correspondence to Ji-Dong Wang or Wen-Sheng Xiang.

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Qi, H., Zhang, J., Hao, ZK. et al. Two novel milbemycin derivatives from the genetically engineered strain Streptomyces avermitilis AVE-H39. J Antibiot 73, 642–645 (2020). https://doi.org/10.1038/s41429-020-0317-2

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