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Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5

The Journal of Antibiotics volume 74, pages 359–362 (2021)Cite this article

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Abstract

In our screening program for new biologically active compounds, a new polyene macrolide, lavencidin (1), along with known compound RKGS-A2215A (2), was isolated from the fermentation broth of Streptomyces lavendulae FRI-5 by changing the composition of liquid medium normally used for the strain. Their structures were elucidated by spectral methods (high-resolution fast-atom bombardment mass spectrometry (HRFABMS) and nuclear magnetic resonance (NMR)). Compound 1 includes a conjugated pentaene moiety together with six hydroxy groups and a carboxylic acid as a side chain. Lavencidin (1) showed moderate growth-inhibitory activity against yeast and was cytotoxic against human cancer cell lines with low-micromolar IC50 values.

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Acknowledgements

This work was supported by a Grant-in-Aid for Scientific Research (C) (Grant number 18K05390) from the Japan Society for the Promotion of Science (JSPS) to SK and by a Grant-in-Aid for Scientific Research on Innovative Areas (Grant number 20H04775) from JSPS to SK. This work was also supported in part by funding from the Institute for Fermentation, Osaka (IFO) to SK; by funding from the Asahi Glass Foundation to SK; and by a New Chemical Technology Research Encouragement Award (Step-up Award) from the Japan Association for Chemical Innovation to SK.

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  1. Deceased: 17 September 2018: Takuya Nihira

Authors and Affiliations

  1. International Center for Biotechnology, Osaka University, Osaka, Japan

    Takuya Yoshioka, Shohei Ueda, Ivy Grace Umadhay Pait, Takuya Nihira & Shigeru Kitani

  2. Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan

    Yasuhiro Igarashi

  3. Science Research Center, Kochi University, Kochi, Japan

    Takushi Namba

  4. MU-OU Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand

    Takuya Nihira

Authors
  1. Takuya Yoshioka
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  2. Yasuhiro Igarashi
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  3. Takushi Namba
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  4. Shohei Ueda
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  5. Ivy Grace Umadhay Pait
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  6. Takuya Nihira
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  7. Shigeru Kitani
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Correspondence to Shigeru Kitani.

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Yoshioka, T., Igarashi, Y., Namba, T. et al. Lavencidin, a polyene macrolide antibiotic from Streptomyces lavendulae FRI-5. J Antibiot 74, 359–362 (2021). https://doi.org/10.1038/s41429-020-00404-z

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