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Design, synthesis, characterization, and biological evaluation of nicotinoyl thioureas as antimicrobial and antioxidant agents

The Journal of Antibiotics volume 74, pages 233–243 (2021)Cite this article

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Abstract

Addressed herein a series of thioureas starting from various amines and nicotinic acid have been synthesized. Notably, thiourea based scaffolds are increasingly employed in medicinal chemistry owing to their tunable physicochemical and structural properties. As well-known from the literature, the pyridine ring contains various biological properties, especially antimicrobial activity. Therefore, we performed the synthesis of biologically important thiourea derivatives containing pyridine ring. The structures of the synthesized compounds were characterized by 1H NMR, 13C NMR and FT-IR. In the second part of the study, newly synthesized compounds were also tested in order to demonstrate their antimicrobial and antioxidant properties. All compounds exhibited moderate activity against all tested bacteria known to cause nosocomial infections, which have acquired resistance to many antibiotics, as compared to the standard antibiotics and also strong antioxidant properties. Therefore, they can be evaluated as possible seeds of agents in the treatment of bacterial infections and many health problems related to aging such as cancer, and neurodegenerative diseases.

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Acknowledgements

No words are sufficient to express my gratitude to Prof. Dr. Arzu Görmez for her mentorship.

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  1. Department of Basic Sciences, Faculty of Science, Erzurum Technical University, 25050, Erzurum, Turkey

    Bünyamin Özgeriş

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Özgeriş, B. Design, synthesis, characterization, and biological evaluation of nicotinoyl thioureas as antimicrobial and antioxidant agents. J Antibiot 74, 233–243 (2021). https://doi.org/10.1038/s41429-020-00399-7

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