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Salicylaldehyde derivatives from a marine-derived fungus Eurotium sp. SCSIO F452

The Journal of Antibiotics volume 74, pages 273–279 (2021)Cite this article

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Abstract

Two pairs of new salicylaldehyde derivative enantiomers, salicylaldehydiums A and B (1 and 2), along with five known analogues were isolated and identified from a marine-derived fungus Eurotium sp. SCSIO F452. Their structures and absolute configuration were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All the new optical pure enantiomers [(+)-1, (-)-1, (+)-2, (-)-2] were evaluated for their cytotoxic and antioxidative activities. Compound (-)-1 exhibited weak cytotoxic activity.

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Acknowledgements

This work was financially supported by the National Key Research and Development Program of China (2019YFC0312503, 2017YFC0506300), National Natural Science Foundation of China (41476136, 41890853, 41776169), Guangdong Provincial Special Fund for Marine Economic Development Project (Yue Natural Resources Contract No. [2020]042), and the Pearl River S&T Nova Program of Guangzhou (201710010136). We gratefully acknowledge help from the equipment public service center (Dr Xiao, Ms Sun, Ms Zhang, and Dr Zheng) in SCSIO for measuring spectroscopic data and support from the Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences.

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Authors and Affiliations

  1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, 510301, Guangzhou, China

    Weimao Zhong, Junfeng Wang, Fazuo Wang & Si Zhang

  2. University of Chinese Academy of Sciences, 19 Yuquan Road, 100049, Beijing, China

    Weimao Zhong

  3. State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, 100 Central Xianlie Road, 510070, Guangzhou, China

    Yuchan Chen & Weimin Zhang

  4. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, 510650, Guangzhou, China

    Xiaoyi Wei

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  1. Weimao Zhong
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Correspondence to Fazuo Wang or Si Zhang.

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Zhong, W., Chen, Y., Wei, X. et al. Salicylaldehyde derivatives from a marine-derived fungus Eurotium sp. SCSIO F452. J Antibiot 74, 273–279 (2021). https://doi.org/10.1038/s41429-020-00395-x

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