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Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029


Two new compounds classified as one new lumazine peptide, penilumamide K (1) and one new sesquiterpene (2), were obtained from the deep-sea derived fungus Aspergillus sp. SCSIO 41029, together with eleven known compounds (313). The structures of 113 including absolute configurations were determined by detailed NMR spectroscopy, HR-ESI-MS, chemical derivatization, and optical rotation data. Among them, compound 1 represents the first lumazine peptide reported from deep-sea derived fungus. The bioactive assay exhibited that compounds 1, 3, 4, 5, 7 and 10 had significant potency against α-glucosidase with IC50 values ranging from 18.61 to 109.06 μΜ. In addition, compounds 4 and 9 showed strong antibacterial activity against Staphylococcus aureus with MIC values of 0.78 and 6.25 μg ml−1, respectively.

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This work was financially supported by National Key Research and Development Program of China (2019YFC0312503), Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (GML2019ZD0406), the National Natural Science Foundation of China (Nos. 21772210 and 41776169), Guangdong MEPP Fund (No. GDOE [2019]A28 and [2020]037), Pearl River S&T Nova Program of Guangzhou (No. 201710010136). We are grateful to Zhihui Xiao, Aijun Sun, Xiaohong Zheng, Yun Zhang, and Xuan Ma in the analytical facility at SCSIO for recording spectroscopic data.

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Correspondence to Junfeng Wang or Yonghong Liu.

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Chen, W., Chen, C., Long, J. et al. Bioactive secondary metabolites from the deep-sea derived fungus Aspergillus sp. SCSIO 41029. J Antibiot 74, 156–159 (2021).

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