One new chromanone derivative, alterchromanone A (1), and four known curvularin-type macrolides (2–5) were isolated from the crude extract of the mangrove-derived endophytic fungus Alternaria longipes. Their structures were elucidated by MS and NMR spectroscopic analyses and by a comparison with data from the literature. The absolute configuration of 1 was assigned by combination of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 exhibited 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 value of 56.3 μg ml−1. According to the structural features of these compounds, the plausible biosynthetic pathways of 1–5 were also proposed.
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This work was supported by the National Key R&D Program of China (2018YFC0311002) and the National Natural Science Foundation of China (21772228 and 21977113).
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Liu, G., Niu, S. & Liu, L. Alterchromanone A, one new chromanone derivative from the mangrove endophytic fungus Alternaria longipes. J Antibiot 74, 152–155 (2021). https://doi.org/10.1038/s41429-020-00364-4
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