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Three novel chromanones with biological activities from the endophytic fungus Phomopsis CGMCC No. 5416

The Journal of Antibiotics volume 73, pages 194–199 (2020)Cite this article

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Abstract

Three undescribed chromanones (1–3) and two known chromanones (4 and 5) were isolated from the culture of endophytic fungus Phomopsis CGMCC No. 5416 from the stems of Achyranthes bidentata. Their structures were determined by spectroscopic analysis. Compounds 1 and 2 showed inhibitory activities against HIV-1 with IC50 values of 20.4 and 32.5 μg ml−1, respectively. Compounds 1–3 displayed moderate cytotoxicity with CC50 values of 36.5–79.3 μg ml−1 against A549, MDA-MB-231, and PANC-1 cell lines. Moreover, compound 3 can induce the early apoptosis of PANC-1 cancer cells with the apoptosis rate of 10.52%.

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Acknowledgements

The work was supported in part by grants from the National Natural Science Foundation of China (No. 81773616), the Shanghai Outstanding Academic Leaders Plan of Shanghai Municipal Science and Technology (17XD1423200), and the Shanghai Natural Science Foundation (16ZR1435400), the National S&T Major Special Project on Major New Drug Innovation (2012ZX09301-002-004).

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Authors and Affiliations

  1. School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China

    Zhijun Yang, Kai Wu & Yixin Xu

  2. Microbial Pharmacology Laboratory, Shanghai University of Medicine & Health Sciences, Shanghai, China

    Zhijun Yang, Kai Wu & Lei Shao

  3. Shanghai Laiyi Center for Biopharmaceutical R&D, Shanghai, China

    Xing Xia & Mei Ge

  4. School of Biotechnology and Pharmaceutical Engineering, West Anhui University, Jinan, China

    Xuejun Wang

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  1. Zhijun Yang
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Correspondence to Mei Ge or Lei Shao.

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Yang, Z., Wu, K., Xu, Y. et al. Three novel chromanones with biological activities from the endophytic fungus Phomopsis CGMCC No. 5416. J Antibiot 73, 194–199 (2020). https://doi.org/10.1038/s41429-019-0270-0

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