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Oregonensins A and B, new meroterpenoids from the culture broth of Ganoderma oregonense and their antioxidant activity

The Journal of Antibiotics volume 73, pages 112–115 (2020)Cite this article

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Abstract

Two new meroterpene derivatives (1 and 2), together with three known compounds (3–5) were isolated from the culture broth of fungus Ganoderma oregonense. Chemical structures of compounds 1–5 were determined using spectroscopic methods. All compounds were tested for 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging efficacy. Compound 1 exhibited significant antioxidant activities with IC50 values of 31.2 and 65.4 μM in the ABTS and DPPH radical scavenging activities, respectively.

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Acknowledgements

This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (NRF-2016R1A2B2014430). Authors thank Ms. Ji-Young Oh, Center for University Research Facility (CURF) at Chonbuk National University, for NMR measurement. This research was supported by “Research Base Construction Fund Support Program” funded by Jeonbuk National University in 2019.

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  1. Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan-si, Korea

    Ji-Yul Kim, E-Eum Woo, Lee Su Ha, Young-Hee Kim, In-Kyoung Lee & Bong-Sik Yun

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Correspondence to Bong-Sik Yun.

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Kim, JY., Woo, EE., Ha, L.S. et al. Oregonensins A and B, new meroterpenoids from the culture broth of Ganoderma oregonense and their antioxidant activity. J Antibiot 73, 112–115 (2020). https://doi.org/10.1038/s41429-019-0248-y

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