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Recent advances in the biosynthesis of nucleoside antibiotics


Nucleoside antibiotics are a diverse class of natural products with promising biomedical activities. These compounds contain a saccharide core and a nucleobase. Despite the large number of nucleoside antibiotics that have been reported, biosynthetic studies on these compounds have been limited compared with those on other types of natural products such as polyketides, peptides, and terpenoids. Due to recent advances in genome sequencing technology, the biosynthesis of nucleoside antibiotics has rapidly been clarified. This review covering 2009–2019 focuses on recent advances in the biosynthesis of nucleoside antibiotics.

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This work is supported by a grant from JSPS KAKENHI (16H06453 to TK).

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Correspondence to Tomohisa Kuzuyama.

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The authors declare that they have no conflict of interest.

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This study is dedicated to Dr Kiyoshi Isono with respect to his long-standing contribution to the study of nucleoside antibiotics.

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Shiraishi, T., Kuzuyama, T. Recent advances in the biosynthesis of nucleoside antibiotics. J Antibiot 72, 913–923 (2019).

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