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Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis

The Journal of Antibiotics volume 73, pages 48–55 (2020)Cite this article

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Abstract

The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.1 with an IC50 value of 5.4 µM.

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Acknowledgements

We thank C. Risdian for assistance in the identification of bacterial strain Act24Zk, A. Gollasch and S. Karwehl for measuring the mass spectra, as well as C. Kakosche for recording NMR spectra and W. Collisi for conduction of bioassays.

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Author notes

  1. These authors contributed equally: Zahra Khosravi Babadi, Enge Sudarman

Authors and Affiliations

  1. Department of Microbiology & Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University GC, Tehran, Iran

    Zahra Khosravi Babadi & Gholam Hossein Ebrahimipour

  2. Microbial Strain Collection, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124, Braunschweig, Germany

    Zahra Khosravi Babadi & Joachim Wink

  3. Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstrasse 7, 38124, Braunschweig, Germany

    Enge Sudarman, Gian Primahana & Marc Stadler

  4. German Centre for Infection Research Association (DZIF), Partner site Hannover-Braunschweig, Inhoffenstrasse 7, 38124, Braunschweig, Germany

    Enge Sudarman, Gian Primahana, Marc Stadler & Joachim Wink

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  1. Zahra Khosravi Babadi
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Correspondence to Joachim Wink.

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Babadi, Z.K., Sudarman, E., Ebrahimipour, G.H. et al. Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis. J Antibiot 73, 48–55 (2020). https://doi.org/10.1038/s41429-019-0223-7

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