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Labrenzbactin from a coral-associated bacterium Labrenzia sp.


A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute configuration of 1 was determined by spectroscopic methods and Marfey’s analysis. Overall, 1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 with MIC values of 25 and 50 µg ml−1, respectively, and cytotoxicity against P388 murine leukemia cells with an IC50 of 13 µM.

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We thank Prof. Yasufumi Hikichi and Dr. Ayami Kanda at Kochi University for providing R. solanacearum SUPP1541.

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The authors declare that they have no conflict of interest.

Correspondence to Yasuhiro Igarashi.

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