Fig. 6 | The Journal of Antibiotics

Fig. 6

From: Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Fig. 6

Biochemistry of ubiquitin-family E1 activating enzymes. The C-terminal carboxylate of Ub or a Ubl (6.1) is adenylated to form a Ub/Ubl-AMP intermediate (6.2), which reacts with a remote catalytic cysteine side-chain thiol nucleophile on the E1 enzyme to form a Ub/Ubl-E1 thioester conjugate (6.3). Ub and Ub E1 (Uba1) structures derived from PDB ID: 4NNJ [215]. Ub ubiquitin, Ubl ubiquitin-like modifier protein

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