Fig. 4 | The Journal of Antibiotics

Fig. 4

From: Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Fig. 4

Biochemistry of class II aminoacyl-tRNA synthetases and related enzymes. a Aminoacyl-tRNA products (4.1) are produced by the same mechanism as in class I aminoacyl-tRNA synthetases (Fig. 3a), but are typically linked to the 3′-hydroxyl nucleophile of the tRNA 3′-ribose. b Asparagine synthetase A catalyzes adenylation of aspartate (4.2) at its β-carboxylate to form an aspartyl-β-AMP intermediate (4.3), which reacts with an ammonia nucleophile to form the primary carboxamide in asparagine (4.4). tRNA structure derived from PDB ID: 1ASY [214]

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