Fig. 3 | The Journal of Antibiotics

Fig. 3

From: Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Fig. 3

Biochemistry of class I aminoacyl-tRNA synthetases and related enzymes. a An amino acid (3.1) is adenylated to form an aminoacyl-AMP intermediate (3.2), which reacts with a tRNA 3′-ribose hydroxyl nucleophile (typically the 2′-hydroxyl) to form an aminoacyl-tRNA ester (3.3). b Pantothenate (3.4) and mycothiol (3.5) biosyntheses involve adenylate-forming enzymes having the same fold as class I aminoacyl-tRNA synthetases. Carboxylic acid substrate-derived fragments are shown in blue; nucleophile-derived fragments are shown in green. tRNA structure derived from PDB ID: 1GTR [213]

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