Fig. 24 | The Journal of Antibiotics

Fig. 24

From: Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Fig. 24

Inhibition of mycobacterial fatty acyl-AMP ligases (FAAL). a FAAL enzymes catalyze adenylation of fatty acids (24.124.3) to form fatty acyl-AMP intermediates (24.424.6), which react with the phosphopantetheine thiol nucleophile on an ACP domain to form fatty acyl-ACP thioester products (24.724.9), which are then used in fatty acid biosynthesis and metabolism. b Fatty acyl-AMS inhibitors (24.1024.12) mimic the fatty acyl-AMP intermediates (24.424.6)

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