Fig. 17 | The Journal of Antibiotics

Fig. 17

From: Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Fig. 17

Inhibition of mycobacterial cysteine ligase (MshC). a MshC catalyzes adenylation of cysteine (17.1) to form a cysteinyl-AMP intermediate (17.2), which reacts with a GlcN-Ins amine nucleophile (17.3) to form a cysteinyl-GlcN-Ins amide product (17.4), en route to mycothiol (3.5). b A cysteinyl-AMS inhibitor (17.5) mimics the cysteinyl-AMP intermediate (17.2). GlcN-Ins 1-d-myo-inosityl-2-amido-2-deoxy-α-d-glucopyranoside

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