Fig. 16 | The Journal of Antibiotics

Fig. 16

From: Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Fig. 16

Inhibition of panthothenate synthetase (PanC). a PanC catalyzes adenylation of pantoate (16.1) to form a pantoyl-AMP intermediate (16.2), which reacts with a β-alanine amine nucleophile to form a pantothenate amide product (3.4), en route to phosphopantetheine (16.3). b A 4-deoxypantoyl-AMS inhibitor (16.4) mimics the pantoyl-AMP intermediate (16.2) but lacks the 4-hydroxy group of pantoyl-AMS (16.5) to avoid decomposition via lactonization of the pantoyl side chain. *Stereochemistry epimeric or as shown

Back to article page