Fig. 11 | The Journal of Antibiotics

Fig. 11

From: Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors

Fig. 11

Biochemistry of NRPS-independent siderophore synthetases. This family typically uses diacid or monofunctionalized derivatives of diacids as substrates and couples them to alcohol or amine nucleophiles. P. crysanthemi AcsD catalyzes desymmetrizing adenylation of citrate (11.1) to form a (3R)-citryl-AMP intermediate (11.2), which reacts with a serine side-chain hydroxyl nucleophile to form an ester product (11.3), en route to the siderophore achromobactin (11.4)

Back to article page