Asperitaconic acids A–C, antibacterial itaconic acid derivatives produced by a marine-derived fungus of the genus Aspergillus

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Abstract

Three new itaconic acid derivatives, asperitaconic acids A–C (13), were isolated from the ethyl acetate extracts of the rice fermentation of a marine-derived fungus Aspergillus niger, and asperitaconic acids A–C were characterized by an itaconic acid unit and an alkyl chain moiety. Their structures were established by interpretation of their spectroscopic data including NMR and HRESIMS. Asperitaconic acids A–C exhibited antibacterial effect against Staphylococcus aureus with MIC values of 16–32 μg/mL, whereas these compounds showed no cytotoxicity against HepG2 and HeLa cancer cell lines.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (41776168, 41706167, 21672084, 41376155, and 81302665), the Ningbo Sci. & Tech. Projects for Common Wealth (2017C10016), the Science and Technology Planning Project of Guangzhou (201710010088 and 201704030042), the National 111 Project of China (D16013), the Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund, and the K.C. Wong Magna Fund in Ningbo University.

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Correspondence to Lijian Ding or Shan He or Shihai Xu.

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