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Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454

The Journal of Antibioticsvolume 71pages601605 (2018) | Download Citation

Abstract

Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.

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Acknowledgements

We thank Dr. Ben Shen (The Scripps Research Institute) for his generous gift of S. sp. 120454. This work was financially supported by Natural Science Foundation of China (81522042, 21572100, 81421091, 81500059, 81673333, and 21672101), and Jiangsu Provincial Key Medical Discipline (laboratory) (no. ZDXKA2016020).

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Affiliations

  1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing, 210023, China

    • Sheng Tao Bo
    • , Zi Fei Xu
    • , Li Yang
    • , Ping Cheng
    • , Ren Xiang Tan
    • , Rui Hua Jiao
    •  & Hui Ming Ge

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The authors declare that they have no conflict of interests.

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Correspondence to Rui Hua Jiao or Hui Ming Ge.

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DOI

https://doi.org/10.1038/s41429-018-0039-x