Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.
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We thank Dr. Ben Shen (The Scripps Research Institute) for his generous gift of S. sp. 120454. This work was financially supported by Natural Science Foundation of China (81522042, 21572100, 81421091, 81500059, 81673333, and 21672101), and Jiangsu Provincial Key Medical Discipline (laboratory) (no. ZDXKA2016020).
Conflict of interest
The authors declare that they have no conflict of interests.