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Kinanthraquinone, a new anthraquinone carboxamide isolated from Streptomyces reveromyceticus SN-593-44

The Journal of Antibioticsvolume 71pages480482 (2018) | Download Citation

Abstract

A new anthraquinone derivative, kinanthraquinone (1) was isolated from Streptomyces reveromyceticus SN-593-44. Its structure was determined by the combination of spectroscopic methods including NMR and MS. Kinanthraquinone had a characteristic carboxamide group and was a rare class of metabolite as an anthraquinone derivative isolated from microbes. It showed moderate cytotoxocity against HL-60 and srcts-NRK cell with IC50 value of 7.9 and 10 μM, respectively.

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Acknowledgements

We thank Dr. M. Uramoto for useful discussion about the structural identification. We also thank Ms A. Okano and H. Aono for an evaluation of biological activity.

Author information

Affiliations

  1. RIKEN Center for Sustainable Resource Science, Natural Product Biosynthesis Research Unit, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    • Hiroshi Takagi
    •  & Shunji Takahashi
  2. RIKEN Center for Sustainable Resource Science, Chemical biology Research Group, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    • Toshihiko Nogawa
    • , Yushi Futamura
    •  & Hiroyuki Osada

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Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Hiroyuki Osada.

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DOI

https://doi.org/10.1038/s41429-017-0020-0

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