Three new isopentylated diphenyl ethers, (1–3), together with two known isopentylated diphenyl ethers derivatives (4 and 5) were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1–3 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds 1–3 showed strong activity with diameter of inhibition zone (IZD) of 21.8 ± 2.4 mm, 16.8 ± 2.2 mm, and 15.6 ± 2.0 mm, respectively.
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Malik IT, Brotz-Oesterhelt H. Conformational control of the bacterial Clp protease by natural product antibiotics. Nat Prod Rep. 2017;34:815–31.
Schinke C, et al. Antibacterial compounds from marine bacteria, 2010–2015. J Nat Prod. 2017;80:1215–28.
Zhang MZ, et al. Using natural products for drug discovery: the impact of the genomics era. Expert Opin Drug Discov. 2017;12:475–87.
Blunt JW, Copp BR, Keyzers RA, Munro MHG, Prinsep MR. Marine natural products. Nat Prod Rep. 2017;34:235–94.
Liu HB, et al. Polybrominated diphenyl ethers: structure determination and trends in antibacterial activity. J Nat Prod. 2016;79:1872–6.
Carvalho PLND, et al. Importance and implications of the production of phenolic secondary metabolites by endophytic fungi: a mini-review. Min Rev Med Chem. 2016;16:259–71.
Deshmukh SK, et al Endophytic fungi: a reservoir of antibacterials. Front Microbiol. 2015;5:715–58.
Gupta S, Kaul S, et al. Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites. Phytochem Rev. 2012;11:487–505.
Hu QF, et al. Xanthones from the fermentation products of the endophytic fungus Phomopsis amygdali. Chem Nat Compds. 2015;51:456–9.
Yuan L, et al. Isolation of xanthones from the fermentation products of the endophytic fungus of Phomopsis amygdali. Chem Nat Compds. 2015;51:460–3.
Meng Y, et al. Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp. Nat Prod Commun. 2015;10:305–8.
Yang HY, et al. Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp. Fitoterapia. 2013;91:189–93.
Huang YF, et al. A new diphenyl ether from an endolichenic fungal strain, Aspergillus sp. Mycosystema. 2012;31:769–74.
Gao HQ, et al. Diorcinols B-E, new prenylated diphenyl ethers from the marine-derived fungus Aspergillus versicolor ZLN-60. J Antibiot. 2013;66:539–42.
Zhou M, et al. Three new prenylated xanthones from Comastoma pedunculatum and their anti-tobacco mosaic virus activity. Phytochem Lett. 2015;11:245–8.
Gong DL, et al. Diphenyl etheric metabolites from Streptomyces sp. neau50. J Antibiot. 2011;64:465–7.
Clinical and laboratory standards institute (CLSI). Third ed. Wayne: Pennsylvania; 2008.
This research was supported by the National Natural Science Foundation of China (Nos. 21462051, 21562049, 31360081 and 31400303), the Research Foundation of China Tobacco Company (Nos. 110201502006) and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd (Nos. 2015539200340277, 2016JC03).
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The authors declare that they have no conflict of interest.
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Li, Z., Yang, H., Li, J. et al. Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii. J Antibiot 71, 359–362 (2018). https://doi.org/10.1038/s41429-017-0006-y
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