Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii

Abstract

Three new isopentylated diphenyl ethers, (13), together with two known isopentylated diphenyl ethers derivatives (4 and 5) were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 13 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds 1–3 showed strong activity with diameter of inhibition zone (IZD) of 21.8 ± 2.4 mm, 16.8 ± 2.2 mm, and 15.6 ± 2.0 mm, respectively.

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Acknowledgements

This research was supported by the National Natural Science Foundation of China (Nos. 21462051, 21562049, 31360081 and 31400303), the Research Foundation of China Tobacco Company (Nos. 110201502006) and the Research Foundation of China Tobacco Yunnan Industrial Co., Ltd (Nos. 2015539200340277, 2016JC03).

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Correspondence to Qiu-Fen Hu or Xue-Mei Li.

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Li, ZJ., Yang, HY., Li, J. et al. Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii. J Antibiot 71, 359–362 (2018). https://doi.org/10.1038/s41429-017-0006-y

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