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Hierarchical supramolecular structure comprising reduction-responsive DNA microspheres and semi-artificial glycopeptide-based micro-asters


Herein, we describe the construction of a hierarchical supramolecular structure comprising reduction-responsive DNA microspheres and semi-artificial glycopeptide-based micro-asters, which are obtained from the (self-)assembled structures of oligonucleotides and a semi-artificial glycopeptide in a single thermal annealing process under aqueous conditions in the presence of Mg2+.

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This work was supported in part by financial support from the JSPS Core-to-Core Program, iGCORE collaboration grant, Gifu University Drug Discovery Collaborative Research 2022, Grant-in-Aid for Scientific Research (C) of the Japan Society for the Promotion of Science (20K05563, AS), and JSPS Research Fellowship for Young Scientists (SLH). Additionally, we acknowledge the Life Science Research Center, Gifu University, for their kind and continuous support. Finally, the authors thank Enago ( for the English language review.

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Correspondence to Masato Ikeda.

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Isogami, A., Higashi, S.L., Okumura, B. et al. Hierarchical supramolecular structure comprising reduction-responsive DNA microspheres and semi-artificial glycopeptide-based micro-asters. Polym J 55, 1103–1107 (2023).

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