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Isolation of hetero-telechelic polyethylene glycol with groups of different reactivity at the chain ends

Abstract

Hetero-telechelic polymers (HTPs) with different reactive functional groups at the chain ends, which can react selectively with other molecules or surfaces to form new chemical bonds, are attractive in the context of reaction selectivity and elaborate polymer modification. However, effective synthetic routes to HTPs remain limited, especially those based on postpolymerization modification processes. Herein, we report a versatile method based on reversed-phase column chromatography for separation of modified poly(ethylene glycol) with a hydroxy group and a maleimide–furan adduct at its α and ω ends. Protection of the maleimide end with furan protects the imide moiety from hydrolysis during the purification process, and the furan protecting group can be reversibly removed by heating. Furthermore, the resulting hetero-telechelic polymers were successfully applied to syntheses of block copolymers.

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Acknowledgements

This research was supported by the AGC Research Collaboration, trust research/joint research funds from the Asahi Kasei Corporation, and the Fujikura Foundation.

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Correspondence to Daisuke Aoki or Hideyuki Otsuka.

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Sato, T., Takashima, R., Aoki, D. et al. Isolation of hetero-telechelic polyethylene glycol with groups of different reactivity at the chain ends. Polym J 54, 1321–1329 (2022). https://doi.org/10.1038/s41428-022-00676-2

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  • DOI: https://doi.org/10.1038/s41428-022-00676-2

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