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Rheological analysis of the interplay between the molecular weight and concentration of hyaluronic acid in formulations of supramolecular HA/FmocFF hybrid hydrogels

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References

  1. 1.

    Du X, Zhou J, Shi J, Xu B. Supramolecular hydrogelators and hydrogels: from soft matter to molecular biomaterials. Chem Rev. 2015;115:13165–307.

    CAS  Article  Google Scholar 

  2. 2.

    Fichman G, Gazit E. Self-assembly of short peptides to form hydrogels: Design of building blocks, physical properties and technological applications. Acta Biomater. 2014;10:1671–82.

    CAS  Article  Google Scholar 

  3. 3.

    Radvar E, Azevedo HS. Supramolecular peptide/polymer hybrid hydrogels for biomedical applications. Macromol Biosci. 2019;19:1800221.

    Article  Google Scholar 

  4. 4.

    Groll J, Burdick J, Cho D, Derby B, Gelinsky M, Heilshorn S, Jüngst T, Malda J, Mironov V, Nakayama K. A definition of bioinks and their distinction from biomaterial inks. Biofabrication. 2018;11:013001.

    CAS  Article  Google Scholar 

  5. 5.

    Böck T, Schill V, Krähnke M, Steinert AF, Tessmar J, Blunk T, Groll J. TGF-β1-modified hyaluronic acid/poly (glycidol) hydrogels for chondrogenic differentiation of human mesenchymal stromal cells. Macromol Biosci. 2018;18:1700390.

    Article  Google Scholar 

  6. 6.

    Baumann B, Jungst T, Stichler S, Feineis S, Wiltschka O, Kuhlmann M, Lindén M, Groll J. Control of nanoparticle release kinetics from 3D printed hydrogel scaffolds. Angew Chemie Int Ed. 2017;56:4623–8.

    CAS  Article  Google Scholar 

  7. 7.

    Stichler S, Böck T, Paxton N, Bertlein S, Levato R, Schill V, Smolan W, Malda J, Teßmar J, Blunk T. Double printing of hyaluronic acid/poly (glycidol) hybrid hydrogels with poly (ε-caprolactone) for MSC chondrogenesis. Biofabrication. 2017;9:044108.

    Article  Google Scholar 

  8. 8.

    Tang C, Smith AM, Collins RF, Ulijn RV, Saiani A. Fmoc-diphenylalanine self-assembly mechanism induces apparent p K a shifts. Langmuir. 2009;25:9447–53.

    CAS  Article  Google Scholar 

  9. 9.

    Smith AM, Williams RJ, Tang C, Coppo P, Collins RF, Turner ML, Saiani A, Ulijn RV. Fmoc-diphenylalanine self assembles to a hydrogel via a novel architecture based on π-π interlocked β-sheets. Adv Mater. 2008;20:37–41.

    CAS  Article  Google Scholar 

  10. 10.

    Raeburn J, Pont G, Chen L, Cesbron Y, Lévy R, Adams DJ. Fmoc-diphenylalanine hydrogels: understanding the variability in reported mechanical properties. Soft Matter. 2012;8:1168–74.

    CAS  Article  Google Scholar 

  11. 11.

    Diaferia C, Morelli G, Accardo A. Fmoc-diphenylalanine as a suitable building block for the preparation of hybrid materials and their potential applications. J Mater Chem B. 2019;7:5142–55.

    CAS  Article  Google Scholar 

  12. 12.

    Aviv M, Halperin-Sternfeld M, Grigoriants I, Buzhansky L, Mironi-Harpaz I, Seliktar D, Einav S, Nevo Z, Adler-Abramovich L. Improving the mechanical rigidity of hyaluronic acid by integration of a supramolecular peptide matrix. ACS Appl Mater Interfaces. 2018;10:41883–91.

    CAS  Article  Google Scholar 

  13. 13.

    Capito RM, Azevedo HS, Velichko YS, Mata A, Stupp SI. Self-assembly of large and small molecules into hierarchically ordered sacs and membranes. Science. 2008;319:1812–6.

    CAS  Article  Google Scholar 

  14. 14.

    Huang R, Qi W, Feng L, Su R, He Z. Self-assembling peptide–polysaccharide hybrid hydrogel as a potential carrier for drug delivery. Soft Matter. 2011;7:6222–30.

    CAS  Article  Google Scholar 

  15. 15.

    Graessley WW. Polymer chain dimensions and the dependence of viscoelastic properties on concentration, molecular weight and solvent power. Polymer. 1980;21:258–62.

    CAS  Article  Google Scholar 

  16. 16.

    Orbach R, Mironi-Harpaz I, Adler-Abramovich L, Mossou E, Mitchell EP, Forsyth VT, Gazit E, Seliktar D. The rheological and structural properties of Fmoc-peptide-based hydrogels: the effect of aromatic molecular architecture on self-assembly and physical characteristics. Langmuir. 2012;28:2015–22.

    CAS  Article  Google Scholar 

  17. 17.

    Gong X, Branford-White C, Tao L, Li S, Quan J, Nie H, Zhu L. Preparation and characterization of a novel sodium alginate incorporated self-assembled Fmoc-FF composite hydrogel. Mater Sci Eng C. 2016;58:478–86.

    CAS  Article  Google Scholar 

  18. 18.

    Chakraborty P, Ghosh M, Schnaider L, Adadi N, Ji W, Bychenko D, Dvir T, Adler‐Abramovich L, Gazit E. Composite of peptide‐supramolecular polymer and covalent polymer comprises a new multifunctional, bio-inspired soft material. Macromol Rapid Commun. 2019;40:1900175.

    Article  Google Scholar 

Download references

Acknowledgements

This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) with project number 326998133-TRR 225 (subprojects A02 and B04) and the German Federal Ministry of Education and Research (BMBF) project SOP-Bioprint with contract number 13XP5071A. We would like to thank Dr Tomasz Jüngst for his suggestions related to the preparation of the manuscript and Mrs Katharina Oberst for her assistance in SEC-MALS characterizations.

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Nadernezhad, A., Forster, L., Netti, F. et al. Rheological analysis of the interplay between the molecular weight and concentration of hyaluronic acid in formulations of supramolecular HA/FmocFF hybrid hydrogels. Polym J 52, 1007–1012 (2020). https://doi.org/10.1038/s41428-020-0358-1

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