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Napier RJ, Adams EJ, Gold MC, Lewinsohn DM. The role of mucosal associated invariant T cells in antimicrobial immunity. Front Immunol. 2015;6:344. https://doi.org/10.3389/fimmu.2015.00344.
Gold MC, Lewinsohn DM. Mucosal associated invariant T cells and the immune response to infection. Microbes Infect. 2011;13:742–8. https://doi.org/10.1016/j.micinf.2011.03.007.
Ioannidis M, Cerundolo V, Salio M. The immune modulating properties of mucosal-associated invariant T cells. Front Immunol. 2020;11:1556. https://doi.org/10.3389/fimmu.2020.01556.
Pellicci DG, Koay HF, Berzins SP. Thymic development of unconventional T cells: how NKT cells, MAIT cells and gammadelta T cells emerge. Nat Rev Immunol. 2020;20:756–70. https://doi.org/10.1038/s41577-020-0345-y.
Liu T, Toor JS, Subedi K, Wang J, Yi Q, Loveless I, et al. Cbf-beta is required for the development, differentiation, and function of murine mucosal-associated invariant T cells. Cell Mol Immunol. 2022;19:1314–6.
Chang JH, Hu H, Sun SC. Survival and maintenance of regulatory T cells require the kinase TAK1. Cell Mol Immunol. 2015;12:572–9. https://doi.org/10.1038/cmi.2015.27.
Liu HH, Xie M, Schneider MD, Chen ZJ. Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci USA 2006;103:11677–82. https://doi.org/10.1073/pnas.0603089103.
Suddason T, Anwar S, Charlaftis N, Gallagher E. T-cell-specific deletion of Map3k1 reveals the critical role for Mekk1 and Jnks in Cdkn1b-dependent proliferative expansion. Cell Rep. 2016;14:449–57. https://doi.org/10.1016/j.celrep.2015.12.047.
Wan YY, Chi H, Xie M, Schneider MD, Flavell RA. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol. 2006;7:851–8. https://doi.org/10.1038/ni1355.
Suddason T, Gallagher E. Genetic insights into Map3k-dependent proliferative expansion of T cells. Cell Cycle. 2016;15:1956–60. https://doi.org/10.1080/15384101.2016.1189042.
Sanjo H, Tokumaru S, Akira S, Taki S. Conditional deletion of TAK1 in T cells reveals a pivotal role of TCRalphabeta+ intraepithelial lymphocytes in preventing lymphopenia-associated colitis. PLoS ONE. 2015;10:e0128761. https://doi.org/10.1371/journal.pone.0128761.
Hartley GE, Edwards ESJ, Aui PM, Varese N, Stojanovic S, McMahon J, et al. Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence. Sci Immunol. 2020;5:eabf8891. https://doi.org/10.1126/sciimmunol.abf8891.
Salou M, Legoux F, Lantz O. MAIT cell development in mice and humans. Mol Immunol. 2021;130:31–6. https://doi.org/10.1016/j.molimm.2020.12.003.
Koay HF, Godfrey DI, Pellicci DG. Development of mucosal-associated invariant T cells. Immunol Cell Biol. 2018;96:598–606. https://doi.org/10.1111/imcb.12039.
We would like to thank the NIH tetramer core for providing MR1 tetramers and Dr. Stephen D Brown for performing irradiation for the bone marrow charisma transfer experiment. We thank all laboratory members for their support and encouragement. This research is partially supported by NIH RO1AI119041 (QSM), Henry Ford Immunology Program grants (T71016, QSM; T71017, LZ), and the Henry Ford Cancer Institute Postdoctoral fellowship program (JW and KS).
The authors declare no competing interests.
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Krevh, R., Wang, J., Zuniga, B. et al. TAK1 is essential for MAIT cell development and the differentiation of MAIT1 and MAIT17. Cell Mol Immunol 20, 854–856 (2023). https://doi.org/10.1038/s41423-023-00999-x